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臺大 niChe 幹細胞與再生醫學研究是：從核心看見無限可能

自 2010 年成立以來，臺大 niChe 實驗室始終以「幹細胞生物學」為核心，不斷向外探索生命科學的未知領域，並致力將基礎研究轉化為實際的臨床與轉譯應用。我們不僅是尖端技術的孵化器，更是科研人才的搖籃——從高中生、大學生到碩博士生及博士後研究員，我們深信每一階段的扎根培育，都是推動科學前進的重要動力。

我們在人類誘導型多能幹細胞（hiPSCs）、癌症幹細胞以及 DNA 摺紙技術上具備獨步的優勢，並將研究能量深度聚焦於以下核心領域：

• 解碼癌症起源，精準開發新世代療法 我們致力於破解腫瘤的生存機制，不僅發現多項發育過程中的轉錄因子與表觀遺傳調節分子，更深入剖析它們如何維持肝癌與大腸癌幹細胞的「腫瘤幹性」（Stemness）。透過理解這些根源機制，我們正積極開發更具專一性且能克服抗藥性的精準癌症治療策略。

• 突破細胞培養限制，建構前沿三維疾病模型 高品質的幹細胞與癌症幹細胞培養技術，是推進細胞療法與疾病研究的基石。我們突破傳統二維培養的限制，積極發展 3D 類器官（Organoids）系統。這些高度還原人體生理微環境的疾病模型，正為新藥開發、毒性測試與個人化幹細胞治療提供最關鍵的測試平台。

• 推演 DNA 奈米科技，打造生醫新穎材料 DNA 摺紙技術（DNA Origami）是當今最具潛力的高精密度「可設計」奈米材料。我們將這項前衛技術轉化為仿生奈米元件，並結合核酸適體（Aptamer）技術對特定生物標記（的精準捕捉，為生醫檢測、奈米感測器及靶向藥物傳遞領域注入嶄新的設計思維與材料選擇。

• 探索幹細胞，外泌體與細胞衰老，開創轉譯醫學新徑 我們持續拓展研究邊界，深入探討細胞衰老機制及外泌體（Exosomes）在分子微環境中的角色。透過解析微小 RNA（miRNA）的精準分選機制與表面蛋白標記，我們期盼在精準醫療與抗老化上取得突破，進一步完善癌症的防護網。

• 鏈結產業需求，實踐科研社會責任 niChe 實驗室不只停留在學術象牙塔，我們積極與多個企業體展開產學合作，致力將實驗室的心血結晶推向產業化。無論是民生生技產品的應用，還是前瞻藥物與診斷工具的開發，我們期盼以科學實力解決真實世界的問題，將研究價值實質回饋給社會。

niChe Lab: Unlocking Infinite Possibilities from the Core

Since its establishment in 2010, the NTU niChe Lab has always centered on "Stem Cell Biology," continuously exploring the uncharted territories of life sciences and dedicating ourselves to translating basic research into practical clinical and translational applications. We are not only an incubator for cutting-edge technology but also a cradle for scientific talent—from high school and undergraduate students to master's and doctoral candidates, as well as postdoctoral researchers. We firmly believe that foundational training at every stage is a crucial driving force in advancing science.

We possess unique advantages in human induced pluripotent stem cells (hiPSCs), cancer stem cells, and DNA origami technology, focusing our research energy deeply on the following core areas:

• Decoding Cancer Origins and Developing Next-Generation Precision Therapies We are dedicated to unraveling the survival mechanisms of tumors. We have not only discovered multiple transcription factors and epigenetic regulators involved in developmental processes but also deeply analyzed how they maintain the "stemness" of liver and colorectal cancer stem cells. By understanding these root mechanisms, we are actively developing highly specific precision cancer treatment strategies capable of overcoming drug resistance.

• Breaking Cell Culture Boundaries to Build Cutting-Edge 3D Disease Models High-quality cultivation techniques for stem cells and cancer stem cells are the cornerstone of advancing cell therapies and disease research. Breaking through the limitations of traditional 2D culture, we are actively developing 3D organoid systems. These disease models, which highly replicate the human physiological microenvironment, provide the most critical testing platforms for new drug development, toxicity screening, and personalized stem cell therapies.

• Advancing DNA Nanotechnology to Create Novel Biomedical Materials DNA origami is currently one of the most promising, high-precision "designable" nanomaterials. We are translating this avant-garde technology into biomimetic nanocomponents. By combining it with aptamer technology for the precise capture of specific biomarkers, we are injecting novel design concepts and material choices into the fields of biomedical diagnostics, nanosensors, and targeted drug delivery.

• Exploring Stem cells, Exosomes and Cellular Senescence to Pioneer New Paths in Translational Medicine We continuously expand our research boundaries by deeply investigating cellular senescence mechanisms and the role of exosomes in the molecular microenvironment. By deciphering the precise sorting mechanisms of microRNAs (miRNAs) and surface protein markers, we aim to achieve breakthroughs in precision medicine and anti-aging, further strengthening the defense network against cancer.

• Linking Industry Needs and Fulfilling Scientific Social Responsibility The niChe Lab does not merely stay in the academic ivory tower. We actively engage in industry-academia collaborations with multiple enterprises, dedicating ourselves to commercializing the lab's innovations. Whether through the application of consumer biotechnology products or the development of forward-looking drugs and diagnostic tools, we hope to solve real-world problems with scientific prowess and tangibly give the value of our research back to society.

攜手推動生醫前沿，將研究化為真實力量 您的慷慨捐助，是推動 niChe 實驗室突破科學瓶頸的重要動能。這份支持將為我們在「癌症精準治療」與「再生醫學應用」的研發上挹注充沛資源，讓尖端技術得以走出實驗室，實質回饋並貢獻於社會。

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